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POLTEKKESSBY » Journal » Jurusan Analis Kesehatan
di-posting oleh noeramelia@poltekkesdepkes-sby.ac.id pada 2021-09-07 10:30:19  •  48 klik          Permohonan Koleksi

Diagnostic work-up of acute myeloid leukemia

disusun oleh Olga K. Weinberg; Aliyah R. Sohani; Parul Bhargava; Valentina Nardi

Tanggal tercipta2020-01-05
Jenis(Tipe)Journal
Bentuk(Format)Pdf link
BahasaInggris
Pengenal(Identifier)POLTEKKESSBY-Journal-12JRLi2017002
No Koleksi12JRLi2017002
No Klasifikasi616. 9 J
Link Publikasihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.24648


Sumber :
Wiley Online Library

Cakupan (Coverage) :
Bidang Kesehatan


[ ANOTASI / ABSTRAK ]

AbstractAcute myeloid leukemia (AML) is characterized by a clonal expansion of undierentiated myeloidprecursors resulting in impaired hematopoiesis and bone marrow failure. In 2016, the WorldHealth Organization (WHO) published revisions to the classication of myeloid neoplasms andacute leukemias. Similar to the 2008 classication, the updated classication incorporates clinicalfeatures, morphology, immunophenotyping, and cytogenetics, with greater emphasis on moleculargenetics, to dene disease entities. This brief review addresses the various components of patho-logic assessment to establish a diagnosis of AML and to help risk stratify patients, with anemphasis on newer techniques used in the detection of mutations with prognostic signicance, aswell as assays employed in the evaluation of minimal residual disease following treatment.



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